When a dead newborn is found, wrapped in bloody sheets, in the bedroom wastebasket of a young novice, psychiatrist Martha Livingston is called in to determine if the seemingly innocent novice, who knows nothing of sex or birth, is competent enough to stand trial for the murder of the baby.

In the year after graduating college, Izzy struggles to navigate the seemingly incessant failures of adulthood, the reality of a substandard dating pool and a debilitating fear of top-sheets, all in between X-Files marathons. Comically unsuccessful in love over the course the year, including five half-hearted relationships with astoundingly self-centered men, Izzy resigns herself to the support of her mother and sister, who are struggling with their own relationship problems. Seeing herself in them, Izzy gradually gains the confidence to be honest and vulnerable.